Peptide Science PE-22-28

PE-22-28 is a synthetic derivative of spadin, a naturally occurring peptide that inhibits the TREK-1 potassium channel. TREK-1 is predominantly found in brain regions responsible for mood regulation, memory, and learning. By blocking this channel, PE-22-28 has shown promise in various research applications:

• Antidepressant Effects: Studies in animal models have demonstrated that PE-22-28 exhibits antidepressant properties, potentially offering an alternative to traditional antidepressant medications.
• Neurogenesis and Synaptogenesis: Research indicates that PE-22-28 can stimulate the growth of new neurons and the formation of synaptic connections, suggesting potential benefits for learning, memory enhancement, stroke recovery, and treatment of neurodegenerative diseases like Alzheimer’s.
• Neuroprotection: Given its influence on TREK-1, PE-22-28 may play a role in protecting neurons from damage, offering potential therapeutic avenues for various neurological conditions.